Palabras clave
segurança hepática
farmacocinética
helmintíases
terapias combinadas
Cómo citar
Resumen
Esta revisión narrativa integra hallazgos de 15 revisiones sistemáticas y metanálisis sobre albendazol oral, centrándose en seguridad hepática, farmacocinética y eficacia terapéutica en diversas helmintiasis. Aunque bien tolerado en general, existen casos infrecuentes de hepatotoxicidad que requieren monitoreo de laboratorio en tratamientos prolongados. La biodisponibilidad de albendazol-sulfoxido muestra alta variabilidad interindividual según edad, estado nutricional y ingesta de alimentos grasos, lo que demanda enfoques personalizados. En cuanto a eficacia, el fármaco es muy activo contra Ascaris lumbricoides y anquilostomas, pero menos eficaz contra Trichuris trichiura y Giardia lamblia, justificando regímenes combinados (ivermectina, praziquantel, corticosteroides) en situaciones específicas. Su papel aislado en filariasis linfática es limitado, sugiriendo protocolos más diversos. Se recomienda actualizar directrices de desparasitación y promover ensayos clínicos para optimizar dosis, seguridad y eficacia.
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